Caroline Curll

Development of genetic medicines for the cardiac and nervous systems.

• Utilized mammalian cell lines for transfection, transduction, and cell-surface binding to determine capsid binding in vitro via fluorescence and qPCR/RT-qPCR readouts
• Independently designed and conducted immunoprecipitation assays for testing novel capsid binding functionality for in vivo development studies
• Optimized cloning strategies for libraries using Gibson assembly techniques for AAV capsid screening
• Generated and developed assays to train AI models for optimal capsid motifs
• Created data packages for conferences such as ASGCT

Research and development in diagnostic devices.

• Developed graphene-based field-effect transistor (FET) sensor-based assays for diagnostic testing
• Supported R&D team to improve surface chemistry modification based on experimental results
• Collaborated with cross-functional teams to optimize experimental protocols and workflows
• Assist in designing ELISA assays to determine LOD for antibody-antigen targets for diagnostic testing
• Developed hybrid ELISA assay on graphene-based FET sensor to validate graphene-based chemistry
• BioDot automated droplet dispenser operation for molecular printing on graphene surface

Research in ribosomal assembly of 16S ribosomal RNA (rRNA).

• Performed site-directed mutagenesis on 16S ribosomal RNA to study functional implications
• Planned, modified, and executed research techniques, procedures, and tests
• Developed effective skills in DNA cloning and bacterial transformation
• Collaborated with other researchers to refine experimental protocols for ribosomal studies
• Presented research findings at departmental meetings, enhancing communication skills
• Conducted literature searches to identify relevant articles for review