Kelly Mullen

Determined and well-rounded individual with more than 20 years working as a Scientist within the Pharmaceutical industry. Sharp and focused professional offering skills in drug design and medicinal chemistry.

• 226th National ACS meeting, New York, Sept 7-11, 2003
• 236th National ACS meeting, Philadelphia, Aug 17-21, 2008
• National Organic Symposium, Boulder, CO June 7-11, 2009
• National Med Chem Symposium, MN May 20-23 2010
• National Med Chem Symposium, AZ May 20-23 2012
• 245th National ACS meeting, New Orleans, Apr 7-11, 2013
• Heterocyclic and Synthetic Conference, FL Mar 2-5 2014
• National Organic Symposium, Davis, CA Jun 23-27, 2017

• 1. Breinlinger, Eric; Burchat, Andrew; Dietrich, Justin; Friedman, Michael; Ihle, David; Kinsman, David; Mullen, Kelly; Osuma, Augustine; Vasudevan, Anil; Wilson, Noel S. Indazoles as Modulators of TNF Signaling US 10273238 Issued Apr 30 2019.
• 2. Argiriadi, Maria; Breinlinger, Eric; Dietrich, Justin D.; Friedman, Michael; Ihle, David; Morytko, Michael; Mullen, Kelly; Osuma, Augustine; Lo Schiavo, Gloria Y.; Wilson, Noel S. Indazoles as Modulators of TNF Signaling From PCT Int. Appl. (2016), WO 2016168633 A1 20161020. US 10160748 B2 Issued Dec 25, 2018.
• 3. Breinlinger, Eric; Burchat, Andrew; Dietrich, Justin; Friedman, Michael; Ihle, David; Kinsman, David; Mullen, Kelly; Osuma, Augustine; Vasudevan, Anil; Wilson, Noel S. From PCT Int. Appl. (2016), WO 2016168638 A1 20161020 Indazoles as Modulators of TNF Signaling US 9879016 B2 Issued Jan 30, 2018.
• 4. Burchat, Andrew, Cusack, Kevin P, Friedman, Michael M.; Gordon, Thomas D. Ihle, David C. Lo Schiavo, Gloria Y, Morytko, Michael J. Mullen, Kelly D. Wang, Lei. From PCT Int. Appl. (2014), WO 2014039757 A1 20140313 Heterocyclic Nuclear Hormone Receptor Modulators US 9193744 Issued Nov 24, 2015.
• 5. Maria A. Argiriadi, Eric C. Breinlinger, David J. Calderwood, Anna M. Ericsson, Kristine E. Frank, Michael Friedman, Dawn M. George, Eric R. Goedken, Michael Z. Hoemann, Nathan S. Josephsohn, Biqin C. Li, Michael J. Morytko, Kelly D. Mullen, Gagandeep Somal, Neil Wishart, Jeffrey W. Voss, Lu Wang. Substituted Dihydropyrazolo[3,4-D]pyrrolo[2,3-B]pyridines and Methods of Use Thereof US 8785639 Issued July 22 2014.
• 6. David J. Calderwood, Bruce Clapham, Philip Cox, Michael Z. Hoemann, Bin Li, Kelly D. Mullen, Gagandeep Somal, Anil Vasudevan, Clara I. Villamil, Noel S. Wilson. Furo[3,2-]pyrimidine Compounds US 8551981 Issued Oct 8 2013.
• 7. David J. Calderwood, Dominique F. Bonafoux, Andrew Burchat, Ping Ding, Kristine E. Frank, Michael Z. Hoemann, Kelly D. Mullen, Heather M. Davis. Triazolopyridazines US 8180803 Issued May 29 2012.
• 8. Anna M. Ericsson, Andrew Burchat, Kristine E. Frank, David J. Calderwood, Lily K. Abbott, Maria A. Argiriadi, David W. Borhani, Kevin P. Cusack, Richard W. Dixon, Thomas D. Gordon, Kelly D. Mullen, Robert V. Talanian, Xiaoyun Wu, Xiaolei Zhang, Lu Wang, Biqin Li, Claude E. Barberis, Neil Wishart. Indazole Compounds US 8008481 Issued Aug 30 2011.
• 9. Patrick Betschmann, Andrew F. Burchat, David J. Calderwood, Michael L. Curtin, Steven K. Davidsen, Heather M. Davis, Robin R. Frey, Howard R. Heyman, Gavin C. Hirst, Peter Hrnciar, Michael R. Michaelides, Melanie A. Muckey, Kelly D. Mullen, Paul Rafferty, Carol K. Wada. THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS US 7202363 Issued April 10 2007.

• 2009 SAC poster session, Worcester MA “Strategies to Optimize the Pharmacokinetic Profile of a Series of p38a Inhibitors”
• 2012 National Med Chem Symposium, Tucson AZ “Triazolopyridazine p38 MAP Kinase Inhibitors”
• 2018 Synthesis Summit, Lake County, IL “EP4 Agonists - Prodrug Approach to Gut Restriction”

• George, Dawn M.; Huntley, Raymond J.; Cusack, Kevin; Duignan, David B.; Hoemann, Michael; Loud, Jacqueline; Mario, Regina; Melvin, Terry; Mullen, Kelly; Somal, Gagandeep; Wang, Lu; Edmunds, Jeremy J. Prodrugs for colon-restricted delivery: design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors. PLoS One. 2018, 13, 1-40.
• Harris, Christopher M.; Ericsson, Anna M.; Argiriadi, Maria A.; Barberis, Claude; Borhani, David W.; Burchat, Andrew; Calderwood, David J.; Cunha, George A.; Dixon, Richard W.; Frank, Kristine E.; Johnson, Eric F.; Kamens, Joanne; Kwak, Silvia; Li, Biqin; Mullen, Kelly D.; Perron, Denise C.; Wang, Lu; Wishart, Neil W.; Xiaoyun; Zhang, Xiaolei; Zmetra, Tami R.; Talanian, Robert V. 2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization. Bioorganic & Medicinal Chemistry Letters. 2010, 20, 334-337.
• Harris, Christopher M.; Ericsson, Anna M.; Argiriadi, Maria A.; Barberis, Claude; Borhani, David W.; Burchat, Andrew; Calderwood, David J.; Cunha, George A.; Dixon, Richard W.; Frank, Kristine E.; Johnson, Eric F.; Kamens, Joanne; Kwak, Silvia; Li, Biqin; Mullen, Kelly D.; Perron, Denise C.; Wang, Lu; Wishart, Neil W.; Xiaoyun; Zhang, Xiaolei; Zmetra, Tami R.; Talanian, Robert V. 2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode. Bioorganic & Medicinal Chemistry Letters. 2010, 20, 330-333.
• Abbott, Lily; Betchmann, Patrick; Burchat, Andrew; Calderwood, David J.; Davis, Heather; Hmciar, Peter; Hirst, Gavin C.; Li, Biqin; Morytko, Michael; Mullen, Kelly; Yang, Bryant. Discovery of thienopyrimidines as Src-family selective Lck inhibitors. Bioorganic & Medicinal Chemistry Letters. 2007, 17, 1167-1171.

• ACS Short Course: “Organic Chemistry of Drug Design and Drug Action” Richard B. Silverman, Boston 2002
• ACS Short Course: “Synthetic Organic Chemistry: Modern Methods and Strategy” Paul Helquist, New York 2003
• ACS Short Course: “Introduction to Drug Metabolism: Role and Practice in Drug Discovery and Development” Donglu Zhang & Mingshe Zhu, Boston 2006
• Multi component chemistry course, Abbott Park March 2007
• Drew School of Medicinal Chemistry, June 2008
• Situational Leadership II, Worcester, MA, Sept 2010
• Internal Med Chem Training sessions, Worcester MA, Jan 2024