SHANJUN HELIAN

Accomplished biostatistician specializing in all phases of clinical trials in oncology, stroke, and vaccine areas. Driving decision maskings through strategic statistical analysis and risk assessment. Experienced at cross-functional communications and managing delivery timeline.

• A double-blind, randomized, multicenter, controlled study to evaluate the immunogenicity, safety, and tolerability of varicella vaccine (VARIVAX) passage extension 34 (PE34) process administered concomitantly with measles, mumps, and rubella vaccine (MMR II)., Silas, P. E., Zissman, E. N., Gardner, J., Helian, S., Lee, A. W., Platt, H. L., Human vaccines & immunotherapeutics, 16, 11, 2634-2640, 2020
• Sparse canonical correlation analysis between an alcohol biomarker and self-reported alcohol consumption., Helian, S., Brumback, B. A., Cook, R. L., Communications in Statistics-Simulation and Computation, 7924-7941, 2017
• Neurocognitive Functioning of Children Treated for High-Risk B-Acute Lymphoblastic Leukemia Randomly Assigned to Different Methotrexate and Corticosteroid Treatment Strategies: A Report from the Children’s Oncology Group., Hardy, K. K., Embry, L., Kairalla, J. A., Helian, S., Devidas, M., Armstrong, D., ..., Loh, M. L., Journal of Clinical Oncology, 35, 23, 2700-2707, 2017
• Reply to IJ Cohen., Hardy, K. K., Embry, L., Kairalla, J. A., Helian, S., Devidas, M., Armstrong, D., ..., Loh, M. L., Journal of Clinical Oncology, 35, 35, 3989-3991, 2017
• Structural Nested Models for Cluster-Randomized Trials., Helian, S., Brumback, B. A., Freeman, M. C., Rheingans, R., Statistical Causal Inferences and Their Applications in Public Health Research, 169-186, Springer International Publishing Switzerland, 2016
• Outcomes of dasatinib plus intensive chemotherapy or stem cell transplant (SCT) for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) on Children’s Oncology Group AALL0622., Slayton, W. B., Kairalla, J. A., Schultz, K. R., Devidas, M., Helian, S., Pulsipher, M., ..., Winick, N. J., Journal of Clinical Oncology, 33, 15_suppl, 10006-10006, 2015

• Sparse Canonical Correlation Analysis Between an Alcohol Biomarker and Self-Reported Alcohol Consumption., 02/16, Florida ASA Chapter Meeting, Tallahassee, FL
• Structural Nested models for Cluster-Randomized Trials., 09/15, Research Day of Public Health and Health Professions, Gainesville, FL
• Analysis of Stratified Clinical Trials with Time-To-Event Endpoints, 08/18, JSM, Vancouver, Canada

• Penalized Correlation and Partial Correlation Analysis, Gainesville, FL, 09/14, 05/16, Developed a new approach of sparse Canonical Correlation Analysis by incorporating Lasso penalty in the linear model with step functions and proved this approach solves an optimization problem., Applied the new sparse Canonical Correlation Analysis method in the WHAT-IF trial to estimate the correlation between the Phosphatidylethanol (PEth) test values and daily self-reported alcohol consumption., Implemented the sparse Canonical Correlation Analysis method using R with weighted cross-validation error and individual sampling weights, and performed simulation studies to verify the method.
• Structural Nested Models for Cluster-Randomized Trials, Gainesville, FL, 10/13, 08/14, Developed structural nested models with different link functions (linear, log linear and logistic) to estimate the causal effect of adherence level to the treatment in a three-armed cluster randomized trial using SAS., Applied structural nested models with different link functions in the school-based WASH study to estimate the cluster-level adherence on an individual-level outcome., Explored three different methodologies to construct confidence intervals: sandwich estimator, bootstrap, and jackknife.